🔥The process of inflammation is maintained by 3 important mechanisms:
✔️Vasodilation ✔️Increased capillary permeability ✔️Migration of leucocytes
🔥WHO IS DOING THESE?
▪️PLASMA DERIVED MEDIATORS:
✔️BRADYKININ –> Vasodilation & Increased capillary permeability
✔️COMPLEMENT MEDIATORS –> Mast cell degranulation –> Vasodilation & Increased capillary permeability + activate neutrophils and phagocyte migration
✔️COAGULATION: Forms a protective clot over the injured area
✔️ FIBRINOLYSIS: Activates neutrophils & macrophages by Fibrin Degradation Products (FDP)
▪️CELL DERIVED MEDIATORS:
✔️HISTAMINE (from basophils and mast cells) –> Vasodilation & Increased capillary permeability
✔️LEUKOTRIENES (from basophils and mast cells) –> chemotaxis of granulocytes
Ⓜ️NEMO> ” leukoTRYenes TRY to catch granulocytes”
✔️TUMOR NECROSIS FACTOR (cytokine from macrophage) –> activates endothelial cells , enhances phagocytosis
Ⓜ️NEMO> “TN(F)™ = F for ‘Fagocytosis’ TM= TNF is from Macrophages ”
✔️CHEMOKINES are chemotactic #cytokines
✔️NITRIC OXIDE (from endothelial cells and macrophages) is a powerful vasodilator and smooth-muscle relaxant.