
IMPORTANT FACTORS THAT AFFECT DRUG METABOLISM IN THE ELDERLY


Cotrimoxazole
Ciprofloxacin
Rifampin
Minocycline
Novobiocin
Vancomycin (problem is it’s high MIC)
Etomidate is an imidazole derivative
It has higher incidence of PONV than other induction agents
It causes pain on injection
A potential for triggering porphyric crisis, has been described
The REVERSIBLE BLOCKADE of the adrenocortical enzymes 11β -hydroxylase and 17α-hydroxylase, reduces BOTH corticosteroid and mineralocorticoid synthesis and the effect LASTS FOR 3–6 hours after a bolus dose.
The effect of a bolus of etomidate is terminated by redistribution of drug to peripheral tissues
The standard dose for induction of anaesthesia is 0.3 mg/ kg







