IMPORTANT FACTORS THAT AFFECT DRUG METABOLISM IN THE ELDERLY

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Antibiotics for infections by Elizabethkingia meningosepticum

Cotrimoxazole
Ciprofloxacin
Rifampin
Minocycline
Novobiocin
Vancomycin (problem is it’s high MIC)

ETOMIDATE BASED ANESTHESIA- FACTS

Etomidate is an imidazole derivative

It has higher incidence of PONV than other induction agents

It causes pain on injection

A potential for triggering porphyric crisis, has been described

The REVERSIBLE BLOCKADE of the adrenocortical enzymes 11β -hydroxylase and 17α-hydroxylase, reduces BOTH corticosteroid and mineralocorticoid synthesis and the effect LASTS FOR 3–6 hours after a bolus dose.

The effect of a bolus of etomidate is terminated by redistribution of drug to peripheral tissues

The standard dose for induction of anaesthesia is 0.3 mg/ kg

VASOACTIVE AGENTS; DO YOU KNOW?

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DISINFECTION: PLASMA STERILIZATION

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TRANSFORMATION OF A PREGNANT LADY (When does the physiology changes back to normal?)

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