Antiepileptic of Choice

FOCAL SEIZURE: Lamotrigine, Carbamazepine, Oxcarbamazepine

GENERALISED TONIC CLONIC SEIZURE (GTCS): Sodium Valproate/Lamotrigine/levetiracetam/zonisamide/topiramate 

ABSENCE SEIZURE: Ethosuximide/ Sodium Valproate, Lamotrigine (Carbamazepine may exacerbate)

MYOCLONIC SEIZURE: Sodium valproate/ Levetiracetam/ Topiramate/ Zonisamide (Carbamazepine, Lamotrigine may exacerbate)

TONIC/ATONIC SEIZURE: Sodium valproate/Lamotrigine/Phenytoin

INFANTILE SPASMS: Steroids (Prednisolone)/ Vigabatrin

Lennox–Gastaut syndrome: Sodium Valproate/Lamotrigine

(Do not offer sodium valproate to women and girls of childbearing potential)

[Ref: NICE guidelines 2012; last update: 2021 ]