Monthly Archives: May 2018

VIVA SCENE: NERVE SUPPLY OF AIRWAY / LARYNX

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Morphine and Hydromorphone

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  • Morphine is metabolised via hepatic system and excreted by renal system
  • It can get accumulated in hepatic/renal dysfunction and obesity
  • Morphine has 2 metabolites:
  • Morphine 6 glucoronide- Active metabolite: responsible for analgesia and sedation
  • Morphine 3 glucoronide: Can cause seizures
  • Morphine has histamine releasing property
  • Hydromorphone is more potent than morphine
  • Hydromorphone doesnt have active metabolites
  • Hydromorphone lacks histamine release