Bedside Weaning Assessment for Myasthenia Gravis

Bedside Test Procedure Normal / Reassuring Value Clinical Significance (Red Flag)
Clinical Assessment Observe for signs of respiratory distress and bulbar weakness (speech, swallowing). No accessory muscle use, effortless breathing, strong cough, clear voice. Tachypnea, accessory muscle use, paradoxical breathing, weak “boggy” cough, slurred/fading voice.
Vital Capacity (VC) Patient takes a maximal inhalation and exhales fully into a bedside spirometer. > 20 mL/kg (ideal body weight) < 15-20 mL/kg, or a declining trend during the breathing trial.
Negative Inspiratory Force (NIF) / MIP Patient makes a maximal inspiratory effort against an occluded airway for ~20 seconds. More negative than -30 cm H₂O Less negative than -30 cm H₂O (e.g., -25, -20), or a worsening trend.
Single Breath Count Patient takes a deep breath and counts aloud steadily (e.g., “1-one-thousand, 2-one-thousand…”). > 25 < 15-20. Indicates severely reduced vital capacity.
Head Lift Test Patient lies supine and lifts their head off the bed, holding the position as long as possible. > 30 seconds < 20 seconds. Correlates with significant diaphragmatic weakness.
Breath-Holding Time After a maximal inhalation, the patient holds their breath for as long as possible. > 30 seconds < 20 seconds. Suggests poor respiratory reserve.

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