AMIDE LOCAL ANESTHETICS

CALCULATION OF THE VOLUME OF OXYGEN / NUMBER OF OXYGEN CYLINDERS REQUIRED FOR A PATIENT TRANSFER

For this, we should know:
1. Oxygen delivered = FiO2 x Minute Volume
2. Duration of the transfer

For e.g. If we are expecting a duration of 2 hours (120 minutes) and we are having Size E cylinders and also need to deliver an FiO2 of 1 @ 6L / min

1. O2 delivered = 1 x 6 = 6L/ min
2. Size E has 660 L of O2, which will suffice for 660/6= 110 minutes ; so for 120 minutes, we need 2 cylinders

ERRORS THAT MAY HAPPEN, IF AN ARTERIAL BLOOD GAS SAMPLE REMAINS FOR QUITE SOME TIME IN ROOM AIR, BEFORE ANALYSIS

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ERRORS IN ABG SAMPLING: CAUSES & CONSEQUENCES

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FUROSEMIDE , THIAZIDES & NSAIDs : A FEW FACTS

Furosemide is a loop diuretic

It interferes with the concentrating capacity of the loop of Henle.

It is effective in patients with renal dysfunction, whereas the thiazides are NOT.

It potentiates the nephrotoxic effects of cephalosporins and the ototoxic effects of aminoglycosides.

NSAIDs inhibit renal prostaglandin, causing sodium to be retained, which reduces the diuresis caused by furosemide.

Furosemide is a venous and arteriolar dilator and thus reduces both preload and afterload in a time frame just before the period of onset of a significant diuresis.

DEXAMETHASONE AS AN ANTIEMETIC; THINGS TO BE KEPT IN MIND

Dexamethasone is an extremely effective antiemetic for children.

Usually a one-off dose of 4 mg is given.

This single dose has not been shown to produce significant adverse effects such as immunosuppression and poor wound healing.

Has rescue antiemetic properties

Most effective if given early on in the operation.

An awake patient may complain of an uncomfortable sensation of perineal warmth, when dexamethasone is given

CELLULAR METABOLISM : A FEW NUMBERS

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IMPORTANT FACTORS THAT AFFECT DRUG METABOLISM IN THE ELDERLY

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