Etomidate is an imidazole derivative

It has higher incidence of PONV than other induction agents

It causes pain on injection

A potential for triggering porphyric crisis, has been described

The REVERSIBLE BLOCKADE of the adrenocortical enzymes 11β -hydroxylase and 17α-hydroxylase, reduces BOTH corticosteroid and mineralocorticoid synthesis and the effect LASTS FOR 3–6 hours after a bolus dose.

The effect of a bolus of etomidate is terminated by redistribution of drug to peripheral tissues

The standard dose for induction of anaesthesia is 0.3 mg/ kg