- For reversal of post-operative respiratory depression and coma: 20-40mcg IV PRN
- For opioid overdose: 40-400 mcg IV PRN
- Infusion: If an infusion is required, commence the infusion with an hourly infusion rate calculated as 2/3rd of the total bolus dose given to achieve the desired opioid reversal effect
- DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY: Dose as in normal renal function
- DOSAGE IN PAEDIATRICS: IV:
- For post-operative respiratory depression or over-sedation, give 0.002mg/kg/dose (i.e. dilute 0.4mg to 20ml and then give 0.1ml/kg/dose). Repeat every 2 minutes x 4 if required, then commence infusion by adding 0.3mg/kg to 30ml 5% dextrose and running at 0-1ml/hr (0.01mg/kg/hr).
- For opiate overdose, give 0.01mg/kg (max 0.4mg) (i.e. dilute 0.4mg to 10ml and give 0.25ml/kg/dose). Repeat every 2 minutes x4 if required, then commence infusion by adding 0.3mg/kg to 30ml 5% dextrose and running at 0-1ml/hr (0.01mg/kg/hr)
The Lay Medical Man 