Tag Archives: phentolamine

PHENTOLAMINE

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  • Competitive alpha blocker
  • Used in hypertensive emergencies like in pheochromocytoma; also in CRPS
  • MOA: 3 times more specific for alpha 1 receptors than alpha 2. Doesn’t bind covalently to receptors; hence reversible. Also has beta agonistic and anti-serotoninergic activity
  • Comes as pale yellow solution 10 mg/mL; dose is 1–5 mg titrated to effect
  • CVS: Vasodilation and  reduce BP, improve coronary artery perfusion, reduce pulmonary artery pressures. Alpha 2 blockade enhances noradrenaline release causing increase in HR and CO
  • RESPIRATORY SYSTEM: Increase FEV1, increase secretions, prevents bronchospasm caused by histamine release
  • Other Side Effects: Nasal congestion, Hypoglycemia (Causes insulin secretion)